The use of biomarkers at the end of the second trimester to predict Gestational Diabetes Mellitus.

Previous studies that investigated the relationship between biomarkers and gestational diabetes mellitus (GDM) generally focused on individual biomarkers with significant heterogeneity in terms of the screening methodologies, diagnostic criteria for GDM and sample handling of glucose within these studies.

This prospective study used an established panel of ten biomarkers to determine if they could predict the diagnosis of GDM.Women with risk factors for GDM were recruited at their first antenatal visit. They attended for an oral glucose tolerance test at 26-28 weeks’ gestation with strict preanalytical handling of glucose samples to minimise glycolysis.

A fasting plasma sample taken simultaneously was stored at -80 °C and analysed in bulk for 10 biomarkers (insulin, c-peptide, glucagon, ghrelin, gastric inhibitory polypeptide (GIP), glucagon like peptide-1 (GLP-1), leptin, visfatin, resistin and plasminogen activator inhibitor-1 (PAI-1)) using the Bio-plex-pro Human Diabetes Assay.

Insulin and C-peptide levels in the third tertile were associated with the development of GDM (adjusted odds ratio (aOR) 2.6, 95 % CI 1.3-5.0, p = 0.005 and aOR 3.7, 95 % CI 1.8-7.4, p < 0.001 respectively, adjusted for maternal obesity).

Elevated levels of ghrelin were associated with a lower odds of developing GDM, after adjustment for maternal obesity.

SKT siRNA

20-abx933470
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

SKT (KIAA1217) Antibody

abx234542-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

Rat GRP78 ELISA Kit

SKT-137-96 1 plate of 96 wells
EUR 632
  • GRP78 is a ubiquitously expressed, 78-kDa glucose-regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the p
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Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

HSP70 ELISA Kit

SKT-105-480 5 plates of 96 wells
EUR 2260
  • HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas
  • Show more
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog

HSC70 ELISA Kit

SKT-106-480 5 plates of 96 wells
EUR 2836
  • HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas
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Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit

SKT-107-480 5 plates of 96 wells
EUR 2702
  • HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral componen
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Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP70 ELISA Kit (High-Sensitivity)

SKT-108-480 5 plates of 96 wells
EUR 2702
  • HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas
  • Show more
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse

HSP27 ELISA Kit

SKT-109-480 5 plates of 96 wells
EUR 2277
  • HSP27s belong to an abundant and ubiquitous family of small heat shock proteins (sHSP). It is an important HSP found in both normal human cells and cancer cells. The basic structure of most sHSPs is a homologous and highly conserved amino acid sequen
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Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human

HSP60 ELISA Kit

SKT-110-480 5 plates of 96 wells
EUR 2277
  • In both prokaryotic and eukaryotic cells, the misfolding and aggregation of proteins during biogenesis and under conditions of cellular stress are prevented by molecular chaperones. Members of the HSP60 family of heat shock proteins are some of the b
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Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HO-1 ELISA Kit

SKT-111-480 5 plates of 96 wells
EUR 2277
  • Heme-oxygenase is a ubiquitous enzyme that catalyzes the initial and rate-limiting steps in heme catabolism yielding equimolar amounts of biliverdin, iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin and the free iron is seq
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Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

HSP65 ELISA Kit

SKT-113-480 5 plates of 96 wells
EUR 2478
  • HSP65 is a member of the HSP60 family of heat shock proteins (2, 3). HSP60s are mitochondrial chaperonins that are typically held responsible for the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. In additi
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Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit

SKT-123-480 5 plates of 96 wells
EUR 2836
  • The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mamma
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Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

HSP70 ELISA Kit (PLANT)

SKT-124-480 5 plates of 96 wells
EUR 2836
  • HSP70 genes encode abundant heat-inducible 70-kDa HSPs (HSP70s). In most eukaryotes HSP70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplas
  • Show more
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human

Nitrotyrosine ELISA Kit

SKT-126-480 5 plates of 96 wells
EUR 1747
  • Nitrotyrosine has been identified as a marker of inflammation and NO production. Nitrotyrosine is formed in presence of the active metabolite NO. Various pathways including the formation of peroxinitrite lead to nitrotyrosine production. Since nitrot
  • Show more
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Dibromo-tyrosine ELISA Kit

SKT-140-480 5 plates of 96 wells
EUR 2195
  • Dibromo-tyrosine is produced by the oxidative bromination of tyrosine residues. This reaction occurs via eosinophil peroxidase (EPO), an enzyme released by activated eosinophils. Upon activation of eosinophils, a respiratory burst occurs releasing el
  • Show more
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

Mouse SKT shRNA Plasmid

20-abx980555
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

JW 480

B5556-10 10 mg
EUR 167

JW 480

B5556-25 25 mg
EUR 325

JW 480

B5556-5 5 mg
EUR 110

JW 480

B5556-50 50 mg
EUR 540

ExpressMax™ Formula 1

137 500 g
EUR 102

Sulforhodamine 101 sulfonyl chloride [Texas Red®] *CAS 82354-19-6*

480 10 mg
EUR 132
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12171501

Mouse Sickle tail protein, Skt ELISA KIT

ELI-29595m 96 Tests
EUR 865

Mouse Sickle tail protein (SKT) ELISA Kit

abx389166-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

MNI 137

B5571-10 10 mg
EUR 366

MNI 137

B5571-50 50 mg
EUR 1347

miRZip-137 anti-miR-137 microRNA construct

MZIP137-PA-1 Bacterial Streak
EUR 684
  • Category: MicroRNA Tools

Human Sickle tail protein homolog, SKT ELISA KIT

ELI-18163h 96 Tests
EUR 824

Handheld Fluorometer 480/530nm

FL480530 1 unit
EUR 1572
Description: Compact handheld fluorometer (exc.480 and em.530nm) for quantitative determination of various analytes in life sciences R&D, food safety and environmental monitoring. Highly sensitive, rapid-reading, reliable and low cost.

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit

EF014796 96 Tests
EUR 689

Recombinant HAdV-2 B-137 Protein (aa 1-137)

VAng-Cr4236-1mgEcoli 1 mg (E. coli)
EUR 3074
Description: HAdV-2 Uncharacterized protein B-137, recombinant protein.

Recombinant HAdV-2 B-137 Protein (aa 1-137)

VAng-Cr4236-500gEcoli 500 µg (E. coli)
EUR 2209
Description: HAdV-2 Uncharacterized protein B-137, recombinant protein.

Recombinant HAdV-2 B-137 Protein (aa 1-137)

VAng-Cr4236-50gEcoli 50 µg (E. coli)
EUR 1521
Description: HAdV-2 Uncharacterized protein B-137, recombinant protein.

Polyclonal ADD3 Antibody (aa431-480)

APR14821G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human ADD3 (aa431-480). This antibody is tested and proven to work in the following applications:

Anti-DDX41 (aa468-480) antibody

STJ73402 100 µg
EUR 359

RNF8 (Ab-137) Antibody

21699-100ul 100ul
EUR 252

RNF8 (Ab-137) Antibody

21699-50ul 50ul
EUR 187

HIST1H1B (Ab-137) Antibody

1-CSB-PA010377PA137nphHU
  • EUR 332.00
  • EUR 335.00
  • 100ul
  • 50ul
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Antigen Affinity Purified
Description: A polyclonal antibody against HIST1H1B (Ab-137). Recognizes HIST1H1B (Ab-137) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; Recommended dilution: WB:1:200-1:2000, IHC:1:20-1:200

rno-miR-137 Primers

MP-r00102 150 ul / 10 uM
EUR 176

hsa-miR-137 Primers

MPH01155 150 ul / 10 uM
EUR 121

mmu-miR-137 Primers

MPM00077 150 ul / 10 uM
EUR 121

SSEA-1 Antibody (Clone MC-480)

3063-25
EUR 272

Polyclonal TAOK1 / TAO1 Antibody (aa431-480)

AMM08087G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TAOK1 / TAO1 (aa431-480). This antibody is tested and proven to work in the following applications:

Zinc Finger Protein 480 (ZNF480) Antibody

20-abx116741
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Zinc Finger Protein 480 (ZNF480) Antibody

abx030192-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Zinc Finger Protein 480 (ZNF480) Antibody

abx030192-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Myosin Light Chain Kinase (480-501)

H-3554.0500 0.5mg
EUR 273
Description: Sum Formula: C120H209N41O28S2; CAS# [313642-00-1]

Myosin Light Chain Kinase (480-501)

H-3554.1000 1.0mg
EUR 466
Description: Sum Formula: C120H209N41O28S2; CAS# [313642-00-1]

anti-Psm1 (fission yeast) antibody, rabbit antibody

63-137 100uL
EUR 414
Description: The anti-Psm1 (fission yeast) antibody, rabbit antibody is available in Europe and for worldwide shipping via Gentaur.

Recombinant Human Complement Factor H-related 2 Protein-GST tag

CTP-137 100ug Ask for price
Description: A 53.46 kDa recombinant human Complement Factor H-related 2 protein with a GST tag at N-terminal expressed in the Wheat Germ (in vitro).

Rabbit Anti-Human Apolipoprotein CIII Polyclonal Antibody

STA-137 100 µg
EUR 496
Description: Rabbit Anti-Human Apolipoprotein CIII Polyclonal Antibody is Affinity purified and suitable for Western blot or ELISA. 100 µg.

WST-1 Cell Proliferation Colorimetric Assay Kit

K2021-480 480 assays
EUR 321

amfiSure PCR Premix, 8-Strip 0.2ml tube with Individual attached cap

P0316-480 5X96 rxns
EUR 529

amfiEco PCR Premix

P0702-480 5x96 rxns
EUR 444

amfiRivert 1-Step RT-PCR Premix

R5004-480 5x96 rxns
EUR 928

Recombinant (E.Coli, GST tag) Hepatitis C Virus (HCV) NS5 Genotype-4 

RP-480 100 ug
EUR 286

p60 v-src (137-157)

5-01682 4 x 1mg Ask for price

RNF8 (Ab-137) Conjugated Antibody

C21699 100ul
EUR 397

p60 v-src (137-157)

H-8535.0500 0.5mg
EUR 212
Description: Sum Formula: C111H168N30O35; CAS# [131023-24-0]

p60 v-src (137-157)

H-8535.1000 1.0mg
EUR 334
Description: Sum Formula: C111H168N30O35; CAS# [131023-24-0]

hsa-miR-137 miRNA Inhibitor

MIH01297 2 x 5.0 nmol
EUR 176

rno-miR-137-3p Primers

MPR00382 150 ul / 10 uM
EUR 176

rno-miR-137-5p Primers

MPR00383 150 ul / 10 uM
EUR 176

mmu-miR-137 miRNA Antagomir

MNM01172 2 x 5.0 nmol
EUR 329

rno??miR-137 miRNA Antagomir

MNR01112 2 x 5.0 nmol
EUR 329

mmu-miR-137 miRNA Inhibitor

MIM01172 2 x 5.0 nmol
EUR 176

rno??miR-137 miRNA Inhibitor

MIR01112 2 x 5.0 nmol
EUR 176

mmu-miR-137-3p Primers

MPM00836 150 ul / 10 uM
EUR 121

mmu-miR-137-5p Primers

MPM00837 150 ul / 10 uM
EUR 121

hsa-miR-137 miRNA Antagomir

MNH01297 2 x 5.0 nmol
EUR 329

miRVec-hsa-miR-137 Plasmid

PVTB00414-3a 2 ug
EUR 356

Protein-A ELISA Kit, 480 tests, Quantitative

800-110-PRA-5 1 pk
EUR 3095

Mouse Olfactory receptor 480, Olfr480 ELISA KIT

ELI-14769m 96 Tests
EUR 865

Opti-Seal qPCR Roche 480 (Low profile)

G913 100 Plates/Case
EUR 302

Opti-Seal qPCR Roche 480 (Low profile)

G914 10 Plates/Box
EUR 76

Recombinant MARV nifE (aa 1-480) Protein

VAng-Wyb3541-1mgEcoli 1 mg (E. coli)
EUR 5247
Description: Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) nitrogenase iron-molybdenum cofactor biosynthesis protein NifE, recombinant protein.

Recombinant MARV nifE (aa 1-480) Protein

VAng-Wyb3541-500gEcoli 500 µg (E. coli)
EUR 3707
Description: Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) nitrogenase iron-molybdenum cofactor biosynthesis protein NifE, recombinant protein.

Recombinant MARV nifE (aa 1-480) Protein

VAng-Wyb3541-50gEcoli 50 µg (E. coli)
EUR 2525
Description: Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) nitrogenase iron-molybdenum cofactor biosynthesis protein NifE, recombinant protein.

Recombinant Rat Akt1 Protein (aa 1-480)

VAng-2932Lsx-1mg 1 mg
EUR 5590
Description: Recombinant Rat Akt1 is expressed in E. coli. (Uniprot ID: P47196)

Recombinant Rat Akt1 Protein (aa 1-480)

VAng-2932Lsx-200g 200 µg
EUR 3363
Description: Recombinant Rat Akt1 is expressed in E. coli. (Uniprot ID: P47196)

Recombinant Rat Akt1 Protein (aa 1-480)

VAng-2932Lsx-50g 50 µg
EUR 2525
Description: Recombinant Rat Akt1 is expressed in E. coli. (Uniprot ID: P47196)

Recombinant Mouse Akt1 Protein (aa 1-480)

VAng-2933Lsx-1mg 1 mg
EUR 5590
Description: Recombinant Mouse Akt1 is expressed in E. coli. (Uniprot ID: P31750)

Recombinant Mouse Akt1 Protein (aa 1-480)

VAng-2933Lsx-200g 200 µg
EUR 3363
Description: Recombinant Mouse Akt1 is expressed in E. coli. (Uniprot ID: P31750)

Recombinant Mouse Akt1 Protein (aa 1-480)

VAng-2933Lsx-50g 50 µg
EUR 2525
Description: Recombinant Mouse Akt1 is expressed in E. coli. (Uniprot ID: P31750)

mmu-miR-137-3p miRNA Antagomir

MNM01173 2 x 5.0 nmol
EUR 329

mmu-miR-137-5p miRNA Antagomir

MNM01174 2 x 5.0 nmol
EUR 329

rno-miR-137-3p miRNA Antagomir

MNR01113 2 x 5.0 nmol
EUR 329

rno-miR-137-5p miRNA Antagomir

MNR01114 2 x 5.0 nmol
EUR 329

mmu-miR-137-3p miRNA Inhibitor

MIM01173 2 x 5.0 nmol
EUR 176

mmu-miR-137-5p miRNA Inhibitor

MIM01174 2 x 5.0 nmol
EUR 176

rno-miR-137-3p miRNA Inhibitor

MIR01113 2 x 5.0 nmol
EUR 176

rno-miR-137-5p miRNA Inhibitor

MIR01114 2 x 5.0 nmol
EUR 176

Anti-IL-17A (aa126-137) antibody

STJ72882 100 µg
EUR 359

Retinoblastoma-Associated Protein Fragment (137 a.a.)

RC712-20 50ug
EUR 169.63
  • Product category: Proteins/Recombinant Proteins/Other

DISH,100X20MM,TCT,PS,S,BK,10/480

430293 10/pk
EUR 305
Description: Lab Cell Culture; Corning TC Dishes

Protein-G (HCPs) ELISA Kit, 480 tests, Quantitative

800-120-PRG-5 1 pk
EUR 3095

Human Zinc finger protein 480, ZNF480 ELISA KIT

ELI-17661h 96 Tests
EUR 824

Recombinant ASFV Ken-089 Protein (aa 1-480)

VAng-2098Lsx-1mg 1 mg
EUR 5728
Description: African swine fever virus (isolate Pig/Kenya/KEN-50/1950) Uncharacterized protein B475L (Ken-089), partial, recombinant protein from E. coli. (Uniprot ID: P0CAH7)

However, approximately half of the women with GDM who were in the obesity category did not have insulin or c-peptide levels in the third tertile.While three of the ten biomarkers were statistically associated with an increased risk of GDM, the large overlap in values between those with normal and abnormal glucose tolerance meant that the biomarkers (alone or in combination) were not useful clinically.